The Rhoads lab focuses on understanding the role of transcriptional processing in regulating metabolism, especially in the context of aging. We use cells in culture, rodent models, and datasets derived from non-human primates to identify and characterize mechanisms by which metabolic output is controlled in response to nutrient intake, aging, and disease development. Our work spans multiple fields, incorporating molecular biology, biochemistry, computational and systems biology, and physiology.
Current Projects (more details coming soon)
Characterization of RNA processing patterns in the brain in response to caloric restriction
Molecular and cellular characterization of DDX39B acetylation
Hepatic RNA processing, systemic metabolism, and aging
The role of DDX39B and transcriptional processing in cancer development